Longitudinal Association of Glycemia and Microalbuminuria: The Framingham Offspring Study

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Longitudinal association of glycemia and microalbuminuria: the Framingham Offspring Study.

OBJECTIVE To assess current and long-term associations of glycemia with microalbuminuria, a marker of generalized endothelial injury. RESEARCH DESIGN AND METHODS We measured clinical characteristics, fasting plasma glucose, and the urinary albumin-to-creatinine ratio (UACR) in 1,311 men and 1,518 women attending the sixth examination cycle (1995-1998) of the Framingham Offspring Study. After ...

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The Framingham Offspring Study

Background. Lipoprotein(a) [Lp(a)J is an atherogenic particle that structurally resembles a low density lipoprotein (LDL) particle but contains a molecule of apolipoprotein(a) attached to apolipoprotein B-100 by a disulfide bond. Because elevated plasma levels of Lp(a) have been shown to be an independent risk factor for coronary artery disease, it is important to define normal ranges for this ...

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The Framingham Offspring Study

Evidence is lacking on whether the duration and timing of low socioeconomic position (SEP) across a person’s life course may be associated with incidence of type 2 diabetes mellitus (T2D). The authors’ objectives were to investigate associations between cumulative SEP and the incidence of T2D in the Framingham Offspring Study (n 1⁄4 1,893; 52% women; mean baseline age 1⁄4 34 years). Pooled logi...

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The Framingham Offspring Study

TYPE 2 DIABETES MELLITUS AND ITS precursor, impaired glucose tolerance (IGT), are associated with increased risk for morbidity and mortality from cardiovascular disease (CVD), particularly coronary heart disease. An increased prevalence of traditional risk factors for atherosclerosis (eg, hypertension, low high-density lipoprotein cholesterol [HDL-C] levels) occurs in type 2 diabetes and IGT, b...

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Fasting and postchallenge glycemia and cardiovascular disease risk: the Framingham Offspring Study.

OBJECTIVE To test the hypothesis that fasting hyperglycemia (FHG) and 2-h postchallenge glycemia (2hPG) independently increase the risk for cardiovascular disease (CVD). RESEARCH DESIGN AND METHODS During 1991-1995, we examined 3,370 subjects from the Framingham Offspring Study who were free from clinical CVD (coronary heart disease, stroke, or intermittent claudication) or medication-treated...

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ژورنال

عنوان ژورنال: Diabetes Care

سال: 2002

ISSN: 0149-5992,1935-5548

DOI: 10.2337/diacare.25.6.977